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Mechanism of Action Comparison IGF-1 LR3 Reduced IGFBP-1, -2, -3 binding affinity Extended circulating half-life (~20-30 hours) Sustained IGF-1 receptor activation Full receptor binding affinity maintained IGF-1 DES Reduced IGFBP binding via truncation Short half-life (~20-30 minutes) Rapid, acute receptor activation Enhanced receptor binding potency reported Research Applications Comparison The choice between IGF-1 LR3 and IGF-1 DES depends on the specific temporal requirements of your research

Ghabili K, Shoja MM, Agutter PS

Updated July 2026 GLP-1 medications produce weight loss unlike anything medicine has offered before and to understand why, and why that weight loss tends to reverse once the drug stops, it helps to know what these drugs actually do inside the body